Metabolic balances of copper in patients with hepatolenticular degeneration submitted to vegetarian and mixed diets.
نویسندگان
چکیده
Besides the use of chelating agents, aiming to produce a rise in cupruresis, a decrease of the positive copper balance in hepatolenticular degeneration has been attempted by means of lowering copper absorption. To this end cation exchange resins and potassium sulphide have been used. Nevertheless, the effectiveness of these drugs is still discussed, some investigators being sceptical (Denny-Brown, 1964; Scheinberg and Sternlieb, 1965), while others (Goldstein, Randall, Gross, and McGuckin, 1965) found an increase in the copper content in faeces promoted by the use of potassium sulphide and mainly of cation-exchange resins, and also that the penicillamine-induced negative copper balance was reinforced by the addition of carbacrylamine resins. Another suggested method of treatment is the use of low copper diets containing 1F0 to 1-5 mg. of copper daily. However, this diet, as well as excluding several largely consumed foods, is very monotonous and has a low nutritional value. Moreover, as Scheinberg and Sternlieb (1965) stated, the net average quantity of copper which must be retained from a daily intake of several milligrams to account for the amounts of copper seen in organs of young adult patients with hepatolenticular degeneration is only about 50 ,tg., as absorption of copper is apparently greater in this disease than in control subjects. On the other hand, the comparative study of high and low copper diets in guinea-pigs (Holbrook, 1961) showed that the copper concentrations change in the blood and liver but not in the central nervous system: cupraemic increases up to 60 ,ig./100 ml. did not raise the copper levels in the nervous tissue. Good clinical results were obtained with high protein diets (Herz and Meyers, 1962; Smith, 1965), sometimes associated with restriction of lipids
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عنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 30 4 شماره
صفحات -
تاریخ انتشار 1967